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64695-96-1

  • Product Name:1-broMo-5-fluoro-2-Methyl-4-nitrobenzene
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Product Details

Purity:99%

Export Industrial grade 64695-96-1 1-broMo-5-fluoro-2-Methyl-4-nitrobenzene

  • Molecular Formula:C7H5BrFNO2
  • Molecular Weight:234.025
  • Boiling Point:287.8±35.0 °C(Predicted) 
  • PSA：45.82000 
  • Density:1.696±0.06 g/cm3(Predicted) 
  • LogP:3.32800 

1-broMo-5-fluoro-2-Methyl-4-nitrobenzene(Cas 64695-96-1) Usage

1-Bromo-5-fluoro-2-methyl-4-nitrobenzene is used as an intermediate of ceritinib.

InChI:InChI=1S/C7H5BrFNO2/c1-4-2-7(10(11)12)6(9)3-5(4)8/h2-3H,1H3

64695-96-1 Relevant articles

ALK KINASE INHIBITOR, AND PREPARATION METHOD AND USE THEREOF

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Paragraph 0106; 0107; 0108; 0109; 0110; 0111, (2017/04/18)

An ALK kinase inhibitor compound as repr...

Ceritinib intermediate and preparation method and application thereof

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Paragraph 0136-0139, (2017/02/28)

The present invention discloses a ceriti...

PROCESS FOR PREPARATION OF CERITINIB

-

Page/Page column 44, (2016/12/26)

The present application relates to a pro...

NOVEL BICYCLIC HETEROCYCLIC COMPOUND

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Page/Page column 74, (2011/11/07)

The present invention aims to provide a ...

64695-96-1 Process route

2-bromo-4-fluorotoluene
1422-53-3

2-bromo-4-fluorotoluene

1-bromo-5-fluoro-2-methyl-4-nitrobenzene
64695-96-1

1-bromo-5-fluoro-2-methyl-4-nitrobenzene

Conditions
Conditions Yield
With sulfuric acid; potassium nitrate; at 0 - 25 ℃; for 2h; Inert atmosphere;
54.3%
With nitric acid; Nitrogen dioxide;
 
With potassium nitrite; sulfuric acid; In water; at 0 - 25 ℃; for 15.75h;
 
1-bromo-5-fluoro-2-methyl-4-nitrobenzene
64695-96-1

1-bromo-5-fluoro-2-methyl-4-nitrobenzene

Conditions
Conditions Yield
With sulfuric acid; potassium nitrate; at -5 - 20 ℃; for 16h;
58%
 
  

64695-96-1 Upstream products

  • 1422-53-3
    1422-53-3

    2-bromo-4-fluorotoluene

64695-96-1 Downstream products

  • 1202858-68-1
    1202858-68-1

    1-bromo-5-isopropoxy-2-methyl-4-nitrobenzene

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