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Purity:99%
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Description |
5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid is an important organic intermediate to synthetize substituted pyrrole products. |
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Uses |
5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic Acid is useful for the synthesis of 5-Bromo-7-azaindolin-2-one derivatives which possesses in vitro activity against selected cancer cell lines. |
InChI:InChI=1/C8H9NO3/c1-4-6(3-10)9-5(2)7(4)8(11)12/h3,9H,1-2H3,(H,11,12)
The presented study explores the antican...
A potential molecular hybridization stra...
The use of covalent irreversible binding...
The invention discloses an enhanced fluo...
ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
| Conditions | Yield |
|---|---|
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With potassium hydroxide; In methanol; water; Reflux;
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99% |
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With potassium hydroxide; In methanol; water; at 70 ℃;
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97% |
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With methanol; water; potassium hydroxide; at 100 ℃; for 2h;
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94% |
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With water; potassium hydroxide; In methanol; for 3h; Reflux;
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94% |
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ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate; With potassium hydroxide; In methanol; water; for 3h;
With hydrogenchloride;
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94% |
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With potassium hydroxide; In methanol;
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93% |
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With potassium hydroxide; water; In methanol; for 3h; Heating / reflux;
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93% |
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ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate; With potassium hydroxide; water; In methanol; for 3h; Heating / reflux;
With hydrogenchloride; In methanol; water; at 20 ℃; pH=3;
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93% |
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ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate; With water; potassium hydroxide; In methanol; at 60 - 70 ℃; for 4 - 6h;
With hydrogenchloride; In methanol; water; at 25 - 30 ℃; pH=4.0;
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93.5% |
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With water; potassium hydroxide; In methanol; at 60 - 70 ℃; for 4 - 6h;
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93.5% |
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With water; potassium hydroxide; In methanol; for 4h; Reflux;
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93% |
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ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate; With potassium hydroxide; water; In methanol; for 3h; Heating / reflux;
With hydrogenchloride; In methanol; water; pH=3;
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93% |
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With sodium hydroxide; In methanol; water; for 4h; Reflux;
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92% |
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With water; sodium hydroxide; In methanol; at 82 - 83 ℃; for 4.5h; Inert atmosphere;
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91% |
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With sodium hydroxide; In methanol; water; for 4.5h; Reflux; Inert atmosphere;
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91% |
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With potassium hydroxide; In methanol; for 3h; Heating;
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90% |
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ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate; With potassium hydroxide; ethanol; water; Heating / reflux;
With hydrogenchloride; water; pH=2;
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89% |
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ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate; With potassium hydroxide; water; In ethanol; Heating / reflux;
With hydrogenchloride; In ethanol; water; pH=2;
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89% |
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ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate; With potassium hydroxide; In water; for 5h; Reflux;
With hydrogenchloride; In water; pH=4;
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89% |
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With potassium hydroxide; In methanol; water; for 4h; Reflux;
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88% |
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With potassium hydroxide; In methanol; water; for 3h; Reflux;
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88% |
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With water; potassium hydroxide; In methanol; at 80 ℃; for 3h;
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86.3% |
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ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate; With water; potassium hydroxide; In ethanol; at 120 ℃; for 1.5h; Inert atmosphere;
With hydrogenchloride; In ethanol; water;
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81% |
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With potassium hydroxide; In methanol; water; for 4h; Reflux;
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40% |
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With sodium hydroxide;
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With potassium hydroxide; In methanol; water;
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1.6 g (93%) |
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With potassium hydroxide; In methanol; water;
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1.6 g (93%) |
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ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate; With water; potassium hydroxide; In methanol; at 75 - 85 ℃; for 6h;
With hydrogenchloride; In water; at 0 - 5 ℃; pH=4 - 5;
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|
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With potassium hydroxide; In methanol; Reflux;
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1.14 g |
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With potassium hydroxide; In water; for 4h; Reflux;
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|
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With potassium hydroxide; for 5h; Reflux;
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1.14 g |
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With water; potassium hydroxide; In methanol; for 3h; Reflux;
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30 g |
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With water; potassium hydroxide; In methanol; for 5h; Reflux;
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ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
5-[5-fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidene-methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic Acid
| Conditions | Yield |
|---|---|
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With potassium hydroxide; In methanol; water;
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93% |
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With potassium hydroxide; In methanol; water;
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93% |
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With potassium hydroxide; In methanol; water;
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93% |
ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate
2-tert-butyl 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate
benzyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
(Z)-N-(2-(dimethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
SU11652