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127641-25-2

  • Product Name:(1S,2R)-N-TOSYLEPHEDRINE
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Product Details

Purity:99%

High Quality 127641-25-2 Global trader, (1S,2R)-N-TOSYLEPHEDRINE 127641-25-2

  • Molecular Formula:C13H19NO
  • Molecular Weight:205.3
  • Vapor Pressure:0mmHg at 25°C 
  • Melting Point:45-48 °C(lit.) 
  • Refractive Index:1.562 
  • Boiling Point:321.268 °C at 760 mmHg 
  • PKA:13.89±0.20(Predicted) 
  • Flash Point:148.089 °C 
  • PSA：23.47000 
  • Density:1.076 g/cm3 
  • LogP:2.14220 

(1S,2R)-N-TOSYLEPHEDRINE(Cas 127641-25-2) Usage

Uses

(1R,2S)-2-Pyrrolidino-1-phenyl-1-propanol, is a chiral building block used in asymmetric synthesis. It is also used as a novel heterodimer chiral amide base for enantioselective deprotonation of ketones.

InChI:InChI=1/C13H19NO/c1-11(14-9-5-6-10-14)13(15)12-7-3-2-4-8-12/h2-4,7-8,11,13,15H,5-6,9-10H2,1H3/t11-,13-/m0/s1

127641-25-2 Relevant articles

Enantioselective Conjugate Addition of Catalytically Generated Zinc Homoenolate

Sekiguchi, Yoshiya,Yoshikai, Naohiko

supporting information, p. 4775 - 4781 (2021/04/07)

We report herein an enantioselective con...

Synthesis method of chiral compound

-

Paragraph 0171-0172, (2020/01/25)

The invention belongs to the technical f...

ANTICANCER COMPOUND PROCESS

-

Page/Page column 34-36, (2019/06/23)

The present invention relates to a proce...

Method for preparing chiral (1R,2S)-1-phenyl-2-(1-pyrrolidyl)propane-1-alcohol

-

Paragraph 0043-0051, (2019/01/23)

The invention provides a new method for ...

127641-25-2 Process route

1,4-dibromo-butane
110-52-1

1,4-dibromo-butane

(1S,2R)-(+)-norphedrine
37577-28-9,58550-13-3,757124-50-8

(1S,2R)-(+)-norphedrine

(1S,2R)-(+)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol
56571-91-6,56571-92-7,127641-25-2,123620-80-4

(1S,2R)-(+)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol

Conditions
Conditions Yield
With sodium hydrogencarbonate; In toluene; at 105 - 115 ℃; for 24h; Temperature; Dean-Stark; Inert atmosphere; Large scale;
87%
With sodium hydrogencarbonate; In toluene; for 48h; Inert atmosphere; Reflux;
82%
With tetra-(n-butyl)ammonium iodide; sodium carbonate; In tetrahydrofuran; for 40h; Heating;
 
With tetra-(n-butyl)ammonium iodide; sodium carbonate; In tetrahydrofuran; for 48h; Heating;
 
With sodium carbonate;
 
1,4-Diiodobutane
628-21-7

1,4-Diiodobutane

(1S,2R)-(+)-norphedrine
37577-28-9,58550-13-3,757124-50-8

(1S,2R)-(+)-norphedrine

(1S,2R)-(+)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol
56571-91-6,56571-92-7,127641-25-2,123620-80-4

(1S,2R)-(+)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol

Conditions
Conditions Yield
With potassium carbonate; In ethanol; Heating;
33%

127641-25-2 Upstream products

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  • 110-52-1
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    1,4-dibromo-butane

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    (SR)-(+/-)-1-phenyl-2-(1-pyrrolidinyl)-1-propanone

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