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Purity:99%
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Uses |
Posaconazole intermediate. Antifungal agent. |
Addition of ethyl Grignard reagent to th...
Heterocyclic compound 1-((2S,3S)-2-(benz...
The present invention discloses an impro...
A method for synthesizing N'-[(2S, 3S)-2...
The invention discloses a method for syn...
ethyl bromide
(S)-N'-(2-(benzyloxy)propylidene)formylhydrazide
![N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide](/upload/2023/5\3a40bef8-c21f-4037-a81b-ffa85b3eb6b3.png)
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
| Conditions | Yield |
|---|---|
|
ethyl bromide; With iodine; magnesium; In tert-butyl methyl ether; at 40 - 55 ℃; for 2h; Inert atmosphere;
(S)-N'-(2-(benzyloxy)propylidene)formylhydrazide; With N,O-bis-(trimethylsilyl)-acetamide; In tert-butyl methyl ether; at 5 - 30 ℃; for 9h; Temperature; Inert atmosphere;
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66% |
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ethyl bromide; With iodine; magnesium; In tert-butyl methyl ether; at 40 - 53 ℃; for 2h; Inert atmosphere;
(S)-N'-(2-(benzyloxy)propylidene)formylhydrazide; With N,O-bis-(trimethylsilyl)-acetamide; In tert-butyl methyl ether; at 5 - 30 ℃; for 9h; Temperature; Inert atmosphere;
|
60% |
|
ethyl bromide; With iodine; magnesium; In tert-butyl methyl ether; at 40 - 55 ℃; for 2h; Inert atmosphere;
(S)-N'-(2-(benzyloxy)propylidene)formylhydrazide; With N,O-bis-(trimethylsilyl)-acetamide; In tert-butyl methyl ether; at 0 - 30 ℃; Inert atmosphere;
|
48 g |
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ethyl bromide; With iodine; magnesium; In tert-butyl methyl ether; at 40 - 55 ℃; Inert atmosphere;
(S)-N'-(2-(benzyloxy)propylidene)formylhydrazide; With N,O-bis-(trimethylsilyl)-acetamide; In tert-butyl methyl ether; at 25 - 30 ℃; for 1.75h; Inert atmosphere;
|
![2-[2S-1-ethyl-2-benzyloxypropylidene]hydrazinecarbaldehyde](/upload/2023/5\c9f9de5c-c59e-45e9-bfd9-8d63b138ce53.png)
2-[2S-1-ethyl-2-benzyloxypropylidene]hydrazinecarbaldehyde
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
| Conditions | Yield |
|---|---|
|
With sodium tetrahydroborate; In isopropyl alcohol; at 0 - 15 ℃; for 3h;
|
9.1 g |
ethylmagnesium bromide
(S)-2-(benzyloxy)propanal
(S)-2-(benzyloxy)-1-(pyrrolidin-1-yl)propan-1-one
methyl (S)-2-(benzyloxy)propanoate
4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-(benzyloxy)pentan-3-yl)-1H-1,2,4-triazol-5(4H)-one
posaconazote
2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)piperazin-1-yl]phenyl]-3H-1,2,4-triazol-3-one