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671815-99-9

  • Product Name:(1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid
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Product Details

Purity:99%

Fast Delivery 671815-99-9 with Factory Price, (1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid

  • Molecular Formula:C14H25NO4
  • Molecular Weight:271.357
  • Melting Point:125-128°C 
  • Boiling Point:416.1±18.0 °C(Predicted) 
  • PKA:4.85±0.10(Predicted) 
  • PSA：79.12000 
  • Density:1.088±0.06 g/cm3(Predicted) 
  • LogP:2.99500 

(1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid(Cas 671815-99-9) Usage

Chemical Properties

White Solid

Uses

Intermediate in the production of Rho kinase inhibitors and neurite outgrowth promoters.

 

671815-99-9 Relevant articles

SMALL MOLECULE INHIBITORS OF ULK1

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Paragraph 0252; 0297, (2021/07/10)

The present technology is directed to co...

A Rho kinase inhibitor Y27632 method for the preparation of compounds

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Paragraph 0043, (2016/10/09)

The invention discloses a preparation me...

A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells

Paleek, Jii,Zweigerdt, Robert,Olmer, Ruth,Martin, Ulrich,Kirschning, Andreas,Draeger, Gerald

experimental part, p. 5503 - 5510 (2011/08/10)

A practical synthesis of the Rho-Kinase ...

1,4-SUBSTITUTED CYCLOHEXANE DERIVATIVES

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Page 96; 97, (2010/02/06)

Allylic compounds represented by the for...

671815-99-9 Process route

(1R,4r)-methyl 4-((R)-1-((tert-butoxycarbonyl)amino)ethyl)cyclohexanecarboxylate

(1R,4r)-methyl 4-((R)-1-((tert-butoxycarbonyl)amino)ethyl)cyclohexanecarboxylate

(1R,4r)-4-((R)-1-((tert-butoxycarbonyl)amino)ethyl)cyclohexanecarboxylic acid
671815-99-9

(1R,4r)-4-((R)-1-((tert-butoxycarbonyl)amino)ethyl)cyclohexanecarboxylic acid

Conditions
Conditions Yield
With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 0 - 25 ℃; for 2h;
89%
With methanol; sodium hydroxide; for 3h;
82%
C<sub>14</sub>H<sub>25</sub>NO<sub>3</sub>

C14H25NO3

(1R,4r)-4-((R)-1-((tert-butoxycarbonyl)amino)ethyl)cyclohexanecarboxylic acid
671815-99-9

(1R,4r)-4-((R)-1-((tert-butoxycarbonyl)amino)ethyl)cyclohexanecarboxylic acid

Conditions
Conditions Yield
With sodium chlorite; sodium dihydrogenphosphate; In water; acetonitrile; tert-butyl alcohol; at 20 ℃; for 0.5h;
83%

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