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76116-20-6

  • Product Name:(R)-1-(2-BROMOPHENYL)ETHANOL
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Product Details

Purity:99%

High Purity Pharmaceutical Intermediates 76116-20-6, (R)-1-(2-BROMOPHENYL)ETHANOL

  • Molecular Formula:C8H9BrO
  • Molecular Weight:201.063
  • Vapor Pressure:0.0172mmHg at 25°C 
  • Melting Point:54-56 °C(lit.)
     
  • Refractive Index:1.572 
  • Boiling Point:243.5 °C at 760 mmHg 
  • PKA:14.01±0.20(Predicted) 
  • Flash Point:113.3 °C 
  • PSA：20.23000 
  • Density:1.47g/cm3 
  • LogP:2.50240 

(R)-1-(2-BROMOPHENYL)ETHANOL(Cas 76116-20-6) Usage

Chemical Properties

white to light yellow crystal powder

Uses

It is the most important dyestuff intermediate.

InChI:InChI=1/C8H9BrO/c1-6(10)7-4-2-3-5-8(7)9/h2-6,10H,1H3/t6-/m1/s1

76116-20-6 Relevant articles

Cinchona-Alkaloid-Derived NNP Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of Ketones

Zhang, Lin,Zhang, Ling,Chen, Qian,Li, Linlin,Jiang, Jian,Sun, Hao,Zhao, Chong,Yang, Yuanyong,Li, Chun

supporting information, p. 415 - 419 (2022/01/12)

Most ligands applied for asymmetric hydr...

Manganese catalyzed asymmetric transfer hydrogenation of ketones

Zhang, Guang-Ya,Ruan, Sun-Hong,Li, Yan-Yun,Gao, Jing-Xing

supporting information, p. 1415 - 1418 (2020/11/20)

The asymmetric transfer hydrogenation (A...

Dynamic Kinetic Resolution of Alcohols by Enantioselective Silylation Enabled by Two Orthogonal Transition-Metal Catalysts

Oestreich, Martin,Seliger, Jan

, p. 247 - 251 (2020/10/29)

A nonenzymatic dynamic kinetic resolutio...

Arene-Immobilized Ru(II)/TsDPEN Complexes: Synthesis and Applications to the Asymmetric Transfer Hydrogenation of Ketones

Doherty, Simon,Knight, Julian G.,Alshaikh, Hind,Wilson, James,Waddell, Paul G.,Wills, Corinne,Dixon, Casey M.

supporting information, p. 226 - 235 (2020/12/31)

The Noyori-Ikariya (arene)Ru(II)/TsDPEN ...

76116-20-6 Process route

2,2,2-Trifluoroacetophenone
434-45-7

2,2,2-Trifluoroacetophenone

(1R)-1-(2-bromophenyl)ethan-1-ol
5411-56-3,114446-55-8,118375-26-1,76116-20-6

(1R)-1-(2-bromophenyl)ethan-1-ol

S(+)-1-phenyl-2,2,2-trifluoroethanol
340-06-7

S(+)-1-phenyl-2,2,2-trifluoroethanol

Conditions
Conditions Yield
With ethanol; NADH; In aq. buffer; at 35 ℃; for 15h; pH=7; stereoselective reaction; Microbiological reaction; Enzymatic reaction;
32.3 % ee
1-(2-bromophenyl)ethanol
5411-56-3

1-(2-bromophenyl)ethanol

2-bromophenyl methyl ketone
2142-69-0

2-bromophenyl methyl ketone

(1S)-1-(2-bromophenyl)ethanol
5411-56-3,76116-20-6,118375-26-1,114446-55-8

(1S)-1-(2-bromophenyl)ethanol

(1R)-1-(2-bromophenyl)ethan-1-ol
5411-56-3,114446-55-8,118375-26-1,76116-20-6

(1R)-1-(2-bromophenyl)ethan-1-ol

Conditions
Conditions Yield
With sodium hydrogencarbonate; sodium bromide; chiral 4,1'-dinaphthyl-3,2'-cyclo[C(Me)2-N(oxyl)-C(Me)2]; In dichloromethane; water; at -15 ℃; for 1.5h; Title compound not separated from byproducts; Electrolysis;
54%
1-(2-bromophenyl)ethanol; With N,N'-bis(salicylidene)-1,2-cyclohexanediaminomanganese(III) chloride; potassium acetate; In dichloromethane; water; for 0.0833333h;
With N-Bromosuccinimide; In dichloromethane; water; at 20 ℃; for 4h; enantioselective reaction; Kinetics;
85 % ee

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