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101403-24-1

Q: What is the CAS number for (S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-2-Naphthalenamine(Rotigotine)?

The CAS number of (S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-2-Naphthalenamine(Rotigotine) is 101403-24-1.

Product Name:(S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-2-Naphthalenamine(Rotigotine)
Molecular Formula:C₁₄H₂₁NO
Molecular Weight:219.327

Inquiry

Product Details

Purity:99%

Top Purity API 101403-24-1 (S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-2-Naphthalenamine(Rotigotine)

Molecular Formula:C14H21NO
Molecular Weight:219.327
Vapor Pressure:0mmHg at 25°C
Refractive Index:1.533
Boiling Point:346.117 °C at 760 mmHg
PKA:10.26±0.20(Predicted)
Flash Point:143.285 °C
PSA：21.26000
Density:1.014 g/cm³
LogP:2.94300

(S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-2-Naphthalenamine(Rotigotine)(Cas 101403-24-1) Usage

InChI:InChI=1/C14H21NO/c1-3-9-15-12-7-8-13-11(10-12)5-4-6-14(13)16-2/h4-6,12,15H,3,7-10H2,1-2H3/t12-/m0/s1

101403-24-1 Relevant articles

New catalytic route for the synthesis of an optically active tetralone-derived amine for rotigotine

Cobley, Christopher J.,Evans, George,Fanjul, Tamara,Simmonds, Shaun,Woods, Amy

, p. 986 - 989 (2016)

Rotigotine is a launched drug for the tr...

Synthesis and pharmacology of the enantiomers of the potential atypical antipsychotic agents 5-OMe-BPAT and 5-OMe-(2,6-di-OMe)-BPAT

Homan, Evert J.,Copinga, Swier,Unelius, Lena,Jackson, David M.,Wikstroem, Hkan V.,Grol, Cor J.

, p. 1263 - 1271 (1999)

The optically pure enantiomers of the po...

Synthesis of Pharmaceutically Relevant 2-Aminotetralin and 3-Aminochroman Derivatives via Enzymatic Reductive Amination

Citoler, Joan,Harawa, Vanessa,Marshall, James R.,Bevinakatti, Han,Finnigan, James D.,Charnock, Simon J.,Turner, Nicholas J.

, p. 24456 - 24460 (2021/10/19)

2-Aminotetralin and 3-aminochroman deriv...

Preparation method of rotigotine

-

Paragraph 0064-0066, (2021/08/11)

The invention relates to the technical f...

Preparation method for rotigotine

-

, (2019/04/17)

The invention discloses a preparation me...

Enantioselective Synthesis of β-Aminotetralins via Chiral Phosphoric Acid-catalyzed Reductive Amination of β-Tetralones

Park, Do Young,Kim, Kyung-Hee,Cheon, Cheol-Hong

, p. 462 - 467 (2017/12/07)

A new protocol for the synthesis of chir...

101403-24-1 Process route

: 3904-24-3
(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride

: 101403-24-1,3899-07-8
(S)-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propylamine hydrochloride

Conditions

Conditions	Yield
With (S)-(+)-N-(3,5-dinitrobenzoyl)-α-phenylglycine; In water; acetonitrile; at 0 - 5 ℃; for 2h;	98%

: 244239-67-6
(S)-N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propionamide

: 101403-24-1,3899-07-8
(S)-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propylamine hydrochloride

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; In tetrahydrofuran; for 42h; Heating;	95%
With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 ℃; for 5h; Reflux;	92.5%

101403-24-1 Upstream products

3904-24-3
(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride
58349-23-8
(S)-(-)-2-(N-benzylamino)-5-methoxytetralin
802294-64-0
propionic acid
101403-23-0
(-)-(2S)-2-(N-benzyl-N-n-propylamino)-5-methoxytetralin

101403-24-1 Downstream products

101470-23-9
Desthienyl-Rotigotine
136247-11-5
N-((S)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-2-(4-nitro-phenyl)-N-propyl-acetamide
129388-80-3
(S)-(-)-2--5-hydroxytetralin
136316-06-8
(S)-(-)-2--5-methoxytetralin