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146986-50-7

  • Product Name:Y-27632 DIHYDROCHLORIDE
  • Molecular Formula:C14H21N3O
  • Molecular Weight:247.34
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Product Details

Purity:99%

Export Y-27632 DIHYDROCHLORIDE 146986-50-7 Good Price

  • Molecular Formula:C14H21N3O
  • Molecular Weight:247.34
  • Boiling Point:462.595 °C at 760 mmHg 
  • PKA:13.53±0.40(Predicted) 
  • Flash Point:233.569 °C 
  • PSA:68.01000 
  • Density:1.137 g/cm3 
  • LogP:2.94700 

Y-27632 DIHYDROCHLORIDE(Cas 146986-50-7) Usage

Uses

Y-27632 Dihydrochloride is a salt analog of Y-27632, which is Rho-kinase inhibitor.

Definition

ChEBI: A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory acti ity against Rho-associated protein kinase (ROCK) enzyme.

Biological Activity

Selective inhibitor of the Rho-associated protein kinase p160ROCK. K i values are 0.14, 26, 25 and >250 μ M for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase respectively. Also inhibits the protein kinase C-related protein kinase, PRK2 (IC 50 = 600nM). Smooth muscle relaxant and orally active in vivo . Increases survival rate of human embryonic stem (hES) cells undergoing cryopreservation.

references

[1] ishizaki t1, uehata m, tamechika i, keel j, nonomura k, maekawa m, narumiya s. pharmacological properties of y-27632, a specific inhibitor of rho-associated kinases. mol pharmacol. 2000 may;57(5):976-83.