pd_meltingpoint:206-208℃ (ethanol )
Purity:99%
Uses |
6-Ketoprogesterone is used in the synthesis and biological evaluation of steroidal deivatives as selective inhibitors of AKR1B10. AKR1B10 is a promising anti-cancer therapeutic target. |
InChI:InChI=1/C21H28O3/c1-12(22)15-4-5-16-14-11-19(24)18-10-13(23)6-8-21(18,3)17(14)7-9-20(15,16)2/h10,14-17H,4-9,11H2,1-3H3/t14-,15+,16-,17-,20+,21+/m0/s1
Pseudomonas sp. strain ST-200 isolated f...
The oxidation of pregn-4-ene-3,20-dione ...
Pregnenolone
Progesterone
6-oxoprogesterone
6ζ-hydroxypregn-4-ene-3,20-dione
Conditions | Yield |
---|---|
In water; at 30 ℃; for 192h; oxidation by persolvent fermentation with Pseudomonas sp. ST-200 in mixture of diphenylmethane-p-xylene;
|
Progesterone
17-hydroxyprogesterone
6-oxoprogesterone
4α-formyl-A-nor-pregnene-3,20-dione
pregn-4-ene-3,12,20-trione
Conditions | Yield |
---|---|
With 2-Picolinic acid; dihydrogen peroxide; iron(III) chloride; In pyridine; acetic acid; for 18h; Further byproducts given; Ambient temperature;
|
19.3% 17.1% 10.7% 5.7% |
Progesterone
Pregnenolone