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2243-08-5

  • Product Name:4-PREGNEN-3,6,20-TRIONE
  • Molecular Formula:C21H28O3
  • Molecular Weight:328.452
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Product Details

pd_meltingpoint:206-208℃ (ethanol )

Purity:99%

High Purity 4-PREGNEN-3,6,20-TRIONE 2243-08-5 In Stock

  • Molecular Formula:C21H28O3
  • Molecular Weight:328.452
  • Vapor Pressure:4.03E-09mmHg at 25°C 
  • Melting Point:206-208℃ (ethanol ) 
  • Refractive Index:1.55 
  • Boiling Point:473.2 °C at 760 mmHg 
  • Flash Point:202.6 °C 
  • PSA：51.21000 
  • Density:1.14g/cm3 
  • LogP:3.90250 

4-PREGNEN-3,6,20-TRIONE(Cas 2243-08-5) Usage

Uses

6-Ketoprogesterone is used in the synthesis and biological evaluation of steroidal deivatives as selective inhibitors of AKR1B10. AKR1B10 is a promising anti-cancer therapeutic target.

InChI:InChI=1/C21H28O3/c1-12(22)15-4-5-16-14-11-19(24)18-10-13(23)6-8-21(18,3)17(14)7-9-20(15,16)2/h10,14-17H,4-9,11H2,1-3H3/t14-,15+,16-,17-,20+,21+/m0/s1

2243-08-5 Relevant articles

Stereospecific oxidation of 3β-hydroxysteroids by persolvent fermentation with Pseudomonas sp. ST-200

Aono, Rikizo,Doukyu, Noriyuki

, p. 1146 - 1151 (2007/10/03)

Pseudomonas sp. strain ST-200 isolated f...

THE OXIDATION OF PROGESTERONE UNDER GoAggIII CONDITIONS

Barton, Derek H. R.,Doller, Dario

, p. 984 - 990 (2007/10/02)

The oxidation of pregn-4-ene-3,20-dione ...

2243-08-5 Process route

Pregnenolone
145-13-1

Pregnenolone

Progesterone
57-83-0

Progesterone

6-oxoprogesterone
2243-08-5

6-oxoprogesterone

6ζ-hydroxypregn-4-ene-3,20-dione

6ζ-hydroxypregn-4-ene-3,20-dione

Conditions
Conditions Yield
In water; at 30 ℃; for 192h; oxidation by persolvent fermentation with Pseudomonas sp. ST-200 in mixture of diphenylmethane-p-xylene;
 
Progesterone
57-83-0

Progesterone

17-hydroxyprogesterone
68-96-2

17-hydroxyprogesterone

6-oxoprogesterone
2243-08-5

6-oxoprogesterone

4α-formyl-A-nor-pregnene-3,20-dione
135574-05-9

4α-formyl-A-nor-pregnene-3,20-dione

pregn-4-ene-3,12,20-trione
55203-20-8

pregn-4-ene-3,12,20-trione

Conditions
Conditions Yield
With 2-Picolinic acid; dihydrogen peroxide; iron(III) chloride; In pyridine; acetic acid; for 18h; Further byproducts given; Ambient temperature;
19.3%
17.1%
10.7%
5.7%

2243-08-5 Upstream products

  • 57-83-0
    57-83-0

    Progesterone

  • 145-13-1
    145-13-1

    Pregnenolone

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