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1268524-70-4

  • Product Name:BET bromodomain inhibitor
  • Molecular Formula:C23H25ClN4O2S
  • Molecular Weight:456.996
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Product Details

Purity:99%

BET bromodomain inhibitor 1268524-70-4 Manufacturer In Stock

  • Molecular Formula:C23H25ClN4O2S
  • Molecular Weight:456.996
  • Boiling Point:610.4±65.0 °C at 760 mmHg 
  • PKA:2.05±0.60(Predicted) 
  • Flash Point:322.9±34.3 °C 
  • PSA：97.61000 
  • Density:1.3±0.1 g/cm3 
  • LogP:4.96690 

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1268524-70-4 Process route

C<sub>33</sub>H<sub>32</sub>ClN<sub>2</sub>O<sub>6</sub>PS

C33H32ClN2O6PS

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

(-)-JQ<sub>1</sub>
1268524-71-5

(-)-JQ1

(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
1268524-70-4

(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

Conditions
Conditions Yield
In tetrahydrofuran; butan-1-ol; at 20 - 90 ℃; for 2h; Overall yield = 3.04 g;
82 % ee
Fmoc-(tBu)Asp-OH
71989-14-5

Fmoc-(tBu)Asp-OH

(-)-JQ<sub>1</sub>
1268524-71-5

(-)-JQ1

(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
1268524-70-4

(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 23 °C
2.1: piperidine / N,N-dimethyl-formamide / 23 °C
2.2: 90 °C
3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -78 - -10 °C
3.2: 0.75 h / -78 - -10 °C
4.1: tetrahydrofuran; butan-1-ol / 2 h / 20 - 90 °C
With piperidine; potassium tert-butylate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; butan-1-ol;
 
Multi-step reaction with 5 steps
1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 23 °C
2.1: piperidine / N,N-dimethyl-formamide / 23 °C
3.1: acetic acid / ethanol / 80 °C
4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -78 - -10 °C
4.2: 0.75 h / -78 - -10 °C
5.1: tetrahydrofuran; butan-1-ol / 2 h / 20 - 90 °C
With piperidine; potassium tert-butylate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; butan-1-ol;
 

1268524-70-4 Upstream products

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    ethanol

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    orthoformic acid triethyl ester

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    acetone

1268524-70-4 Downstream products

  • 1426257-53-5
    1426257-53-5

    8-{2-[(S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetyl}-8-azabicyclo[3.2.1]octan-3-one

  • 1426257-54-6
    1426257-54-6

    2-[(S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1-(2-oxa-6-azaspiro[3.3]hept-6-yl)ethan-1-one

  • 1426257-55-7
    1426257-55-7

    2-[(S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)ethan-1-one

  • 1426257-56-8
    1426257-56-8

    2-[(S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1-(2-oxa-6-azaspiro[3.4]oct-6-yl)ethan-1-one

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