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118-00-3

  • Product Name:Guanosine
  • Molecular Formula:C10H13N5O5
  • Molecular Weight:283.244
  • Appearance:crystalline
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Product Details

pd_meltingpoint:250 °C (dec.)(lit.)

Appearance:crystalline

Purity:99%

Guanosine 118-00-3 Powder In Bulk Supply

  • Molecular Formula:C10H13N5O5
  • Molecular Weight:283.244
  • Appearance/Colour:crystalline 
  • Vapor Pressure:2.44E-25mmHg at 25°C 
  • Melting Point:250 °C (dec.)(lit.) 
  • Refractive Index:-76 ° (C=1, 1mol/L NaOH) 
  • Boiling Point:775.9°C at 760 mmHg 
  • PKA:pK1:1.9(＋1);pK2:9.25(0);pK3:12.33(OH) (25°C) 
  • Flash Point:423.1oC 
  • PSA：159.51000 
  • Density:2.258 g/cm3 
  • LogP:-2.10550 

Guanosine(Cas 118-00-3) Usage

Description

Guanosine is a purine nucleoside, in which the guanine attached to the C1 carbon of a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Its phosphorylated derivatives include GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP (guanosine diphosphate), and GTP (guanosine triphosphate). These guanosine derivatives are very important in various biochemical processes, such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction, and intracellular signal transduction. Guanosine is thought to have neuroprotective properties. It can reduce neuroinflammation, oxidative stress, and excitotoxicity, as well as exerting trophic effects in neuronal and glial cells.?It is shown to be protective in central nervous system diseases including ischemic stroke, Alzheimer’s disease, Parkinson’s disease, spinal cord injury, nociception, and depression. Guanosine is found to be associated with purine nucleoside phosphorylase (PNP) deficiency, which is an inborn error of metabolism.

Reference

L. E. B. Bettio, J. Gil-Mohapel, A. L. S. Rodrigues, Guanosine and its role in neurophathologies, Purinergic Signal, 2016, vol. 12, pp. 411-426

Chemical Properties

White, crystalline powder; odorless; mild saline taste. Very slightly soluble in cold water; soluble in boiling water, dilute mineral acids, hot acetic acid, and dilute bases; insoluble in alcohol, ether, chloroform, and benzene.

Uses

A constituent of nucleic acids.

Definition

A NUCLEOSIDE present in DNA and RNA and consisting of guanine linked to D-ribose via a β-glycosidic bond.

General Description

Guanosine is an aromatic organic molecule and a purine nucleoside. It is present in the cerebrospinal fluid, intestinal cells, blood-brain barrier and in brain microvessels.

Biochem/physiol Actions

Guanosine nucleoside elicits cellular effect as the guanine-based purinergic system. It modulates glutamate uptake by glutamate transporters. It may have neuroprotective functionality in central nervous system disorders. Guanosine promotes neurite arborization, outgrowth, proliferation and differentiation. Administration of guanosine replenished GTP and elicits protective function in renal ischemic injury.

Purification Methods

It crystallises from water as a dihydrate. Dry it at 110o.[Beilstein 26/18 V 81.]

InChI:InChI=1/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5+,6-,9+/m1/s1

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Paragraph 0124-0126; 0131; 0134, (2020/05/12)

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118-00-3 Process route

Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-[2-acetylamino-6-(2,4,6-triisopropyl-benzenesulfonyloxy)-purin-9-yl]-tetrahydro-furan-3-yl ester

Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-[2-acetylamino-6-(2,4,6-triisopropyl-benzenesulfonyloxy)-purin-9-yl]-tetrahydro-furan-3-yl ester

2?amino?9?(β?D?ribofuranosyl)purine
4546-54-7

2?amino?9?(β?D?ribofuranosyl)purine

guanosine
118-00-3

guanosine

Conditions
Conditions Yield
With palladium diacetate; triethylammonium formate; methylamine; Yield given. Multistep reaction. Yields of byproduct given; 1.) dioxane, 90 deg C;
 
highly polymerized dsDNA from salmon testes

highly polymerized dsDNA from salmon testes

protoanemonin
108-28-1

protoanemonin

furfural
98-01-1

furfural

Malondialdehyde
542-78-9

Malondialdehyde

N-oxycarbonylmethyl-5-methylene-Δ3-pyrrolin-2-one

N-oxycarbonylmethyl-5-methylene-Δ3-pyrrolin-2-one

G
118-00-3

G

CYTIDINE
65-46-3

CYTIDINE

thymidine
50-89-5,28854-96-8,3545-96-8,50-88-4

thymidine

adenosine
58-61-7

adenosine

Conditions
Conditions Yield
With carbonatopentamminecobalt(III) nitrate hemihydrate; In aq. phosphate buffer; at 20 ℃; for 0.133333h; pH=6.9; UV-irradiation;
 

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