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pd_meltingpoint:293 °C
Purity:99%
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4-Hydroxy-7-methoxyquinazolin-6-yl Ester Acetic Acid exhibit potent inhibitory activity against VEGFR-2/HDAC and a human breast cancer cell line MCF-7.
acetic anhydride
3H-6,7-dimethoxyquinazolin-4-one
6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one
| Conditions | Yield |
|---|---|
|
3H-6,7-dimethoxyquinazolin-4-one; With methanesulfonic acid; DL-methionine; at 120 ℃; for 24h;
acetic anhydride; With pyridine; at 100 ℃; for 22h;
|
87% |
|
With methanesulfonic acid; DL-methionine; Multistep reaction; 1.) 100 deg C, 3 h, 2.) Py;
|
acetic anhydride
6-hydroxy-7-methoxyquinazolin-4(3H)-one
6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one
| Conditions | Yield |
|---|---|
|
With pyridine; at 100 ℃; for 4h;
|
99% |
|
With pyridine; at 100 ℃; for 2h;
|
99% |
|
With pyridine; at 100 ℃; for 2h;
|
96.6% |
|
With pyridine; In N,N-dimethyl-formamide; at 40 - 45 ℃; for 1h;
|
96% |
|
With pyridine; at 100 ℃; for 4h;
|
93% |
|
With pyridine; at 100 ℃; for 4h;
|
93% |
|
In pyridine; at 116 ℃; for 3h;
|
82% |
|
at 120 - 125 ℃; for 3h;
|
75% |
|
With pyridine; at 100 ℃; for 6h;
|
74% |
|
In pyridine; Inert atmosphere;
|
62% |
|
With pyridine; dmap; at 100 ℃; for 4h;
|
60% |
|
With pyridine; at 100 ℃; for 4h;
|
53% |
|
With pyridine; at 20 - 100 ℃; for 3h;
|
53% |
|
With pyridine; at 100 ℃; for 3h;
|
53% |
|
With pyridine; at 100 ℃;
|
51% |
|
With pyridine; at 100 ℃; for 6h;
|
51% |
|
With pyridine; for 3h; Heating / reflux;
|
50% |
|
With pyridine; at 100 ℃; for 2h;
|
41.3% |
|
With pyridine; dmap; at 100 ℃; for 6h; Inert atmosphere;
|
40% |
|
With pyridine;
|
|
|
With pyridine; dmap; at 100 ℃; for 6h;
|
|
|
In pyridine; for 3h; Heating / reflux;
|
|
|
With pyridine; for 3h; Heating / reflux;
|
|
|
With pyridine; at 100 ℃; for 4h;
|
|
|
With pyridine; dmap; at 0 - 20 ℃; for 12h; Inert atmosphere;
|
|
|
With pyridine; dmap; at 100 ℃;
|
|
|
With dmap; In pyridine;
|
|
|
With pyridine; dmap; at 0 - 20 ℃; for 12h;
|
|
|
With pyridine; dmap; at 0 - 20 ℃; for 12h;
|
|
|
With pyridine; at 20 ℃;
|
|
|
With pyridine; for 3h; Heating / reflux;
|
|
|
acetic anhydride; 6-hydroxy-7-methoxyquinazolin-4(3H)-one; With pyridine; at 100 ℃; for 1h;
With dmap; for 5h;
|
|
|
With pyridine; In N,N-dimethyl-formamide; at 40 - 45 ℃; for 1h;
|
117 g |
|
With pyridine; Reflux;
|
The CAS number of 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate is 179688-53-0.
More information of 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate 179688-53-0 are:
|
CAS Number |
179688-53-0 |
|
Density |
1.395 g/cm3 |
|
Melting Point |
293 °C |
|
Boiling Point |
390.518 °C at 760 mmHg |
|
Flash Point |
189.979 °C |
|
Vapor Pressure |
0mmHg at 25°C |
|
Refractive Index |
1.612 |
|
HS CODE |
2933990090 |
|
PSA |
81.28000 |
|
LogP |
0.85700 |
|
Pka |
0.67±0.20(Predicted) |
Synonyms for 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate 179688-53-0:6-Acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one;6-Acetoxy-7-methoxyquinazolin-4(3H)-one;6-Acetoxy-7-methoxyquinazolin-4-one;Acetic acid 4-hydroxy-7-methoxyquinazolin-6-yl ester;3,4-Dihydro-4-oxo-6-acetyloxy-7-methoxyquinazoline;4(1H)-Quinazolinone,6-(acetyloxy)-7-methoxy- (9CI);3,4-Dihydro-4-oxo-6-acetoxy-7-methoxyquinazoline;
The chemical formula of 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate is C11H10N2O4 which containing 11 Carbon atoms,10 Hydrogen atoms,2 Nitrogen atoms and 4 Oxygen atoms,and the molecular weight of 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate is 234.211.
3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate is a brown solid powder with potent inhibitory activity against VEGFR-2/HDAC and a human breast cancer cell line MCF-7.
InChI:InChI=1/C11H10N2O4/c1-6(14)17-10-3-7-8(4-9(10)16-2)12-5-13-11(7)15/h3-5H,1-2H3,(H,12,13,15)
Relevant articles related to 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate:
|
Article |
Source |
|
Polysubstituted quinazoline compound and application thereof |
- Paragraph 0099-0101, (2020/11/12) |
|
Absolute Binding Free Energy Calculation and Design of a Subnanomolar Inhibitor of Phosphodiesterase-10 |
Li, Zhe,Huang, Yiyou,Wu, Yinuo,Chen, Jingyi,Wu, Deyan,Zhan, Chang-Guo,Luo, Hai-Bin , p. 2099 - 2111 (2019/02/26) |
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