• Product Name:(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
  • Molecular Formula:C10H8F6O
  • Molecular Weight:258.163

Product Details



(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 127852-28-2 Powder In Medicine with Global USP Fast Delivery

  • Molecular Formula:C10H8F6O
  • Molecular Weight:258.163
  • Vapor Pressure:0.746mmHg at 25°C 
  • Melting Point:53-58℃ 
  • Refractive Index:1.418 
  • Boiling Point:175.8 °C at 760 mmHg 
  • PKA:13.99±0.20(Predicted) 
  • Flash Point:60.1 °C 
  • PSA:20.23000 
  • Density:1.376 g/cm3 
  • LogP:3.77750 

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol(Cas 127852-28-2) Usage


(R)-[3,5-bis (trifluoromethyl) phenyl] ethanol is an important chiral intermediate for the synthesis of novel chemotherapeutic and antiemetic drugs NK-1 receptor antagonists. Antidepressants have good potential efficacy in treating a range of central and peripheral nervous system depressions.


At present, the methods for preparing optically pure (R)-[3,5-bis (trifluoromethyl) phenyl] ethanol include chemical methods and biological methods. Chemical synthesis requires the use of expensive transition metal Ru and other chemical catalysts, complicated steps, harsh reaction conditions, high energy consumption, large pollution, and low yield. Biological law is the use of free enzymes or whole cells for catalytic preparation. It has the characteristics of mild reaction conditions, high catalytic efficiency, and strong specificity.

Chemical Properties

White fine crystalline powder

General Description

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is a key intermediate for the synthesis of aprepitant, a potent human neurokinin-1 (NK-1) receptor.

InChI: InChI=1S/C10H8F6O/c1-5(17)6-2-7(9(11,12)13)4-8(3-6)10(14,15)16/h2-5,17H,1H3/t5-/m1/s1  

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Relevant articles

Asymmetric Hydrogenation of 3,5-Bistrifluoromethyl Acetophenone in Pilot Scale with Industrially Viable Ru/Diphosphine-Benzimidazole Complexes

Xu, Liang,Huang, Zhi-Hong,Sandoval, Christian A.,Gu, Lian-Quan,Huang, Zhi-Shu

, p. 1137 - 1141 (2014)

A novel efficient asymmetric hydrogenati...

Development of an Immobilized Ketoreductase for Enzymatic (R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanol Production

Hongmei Li*, Johannah Moncecchi, and Matthew D. Truppo

, Org. Process Res. Dev. 2015, 19, 7, 695–700

The development of an immobilized ketoreductase via covalent binding on resin EC-HFA has demonstrated that it is highly active and stable in organic solvents and can be recycled and reused many times in both batch mode and flow reactor mode.

Efficient synthesis of (1R)-[3,5-bis(trifluoromethyl)phenyl] ethanol, a key intermediate for aprepitant, an NK-1 receptor antagonist

Vankawala, Pravinchandra J.,Kolla, Naveenkumar,Elati, Chandrashekar R.,Sreenivasulu,Kumar, K. Arun,Anjaneyulu, Yerrimilli,Venkatraman, Sundaram,Bhattacharya, Apurba,Mathad, Vijayavitthal T.

, p. 3439 - 3446 (2007)

Enzyme-catalyzed efficient synthesis of ...

Total production of (R)-3,5-bistrifluoromethylphenyl ethanol by asymmetric reduction of 3,5-bis(trifluoromethyl)-acetophenone in the submerged culture of Penicillium expansum isolate

Kurbanoglu, Esabi B.,Zilbeyaz, Kani,Taskin, Mesut,Kurbanoglu, Namudar I.

, p. 2759 - 2763 (2009)

A total of 82 fungal isolates were scree...

Bioreduction of 3,5-bis(trifluoromethyl)acetophenone using ionic liquid as a co-solvent catalyzed by recombinant Escherichia coli cells

Wang, Nengqiang,Li, Jun,Sun, Jing,Huang, Jin,Wang, Pu

, p. 119 - 125 (2015)

We investigated the asymmetric bioreduct...

Microbial and homogenous asymmetric catalysis in the reduction of 1-[3,5-bis(trifluoromethyl)phenyl]ethanone

Gelo-Pujic, Mirjana,Le Guyader, Frederic,Schlama, Thierry

, p. 2000 - 2005 (2006)

Two complementary approaches for the ena...

Identification of ketone reductase ChKRED20 from the genome of Chryseobacterium sp. CA49 for highly efficient anti-Prelog reduction of 3,5-bis(trifluoromethyl)acetophenone

Liu, Yan,Tang, Tuo-Xian,Pei, Xiao-Qiong,Zhang, Chao,Wu, Zhong-Liu

, p. 1 - 8 (2014)

A strain of Chryseobacterium sp. CA49 wa...

Scalable, efficient process for the synthesis of (R)-3,5- bistrifluoromethylphenyl ethanol via catalytic asymmetric transfer hydrogenation and isolation as a DABCO inclusion complex

Hansen, Karl B.,Chilenski, Jennifer R.,Desmond, Richard,Devine, Paul N.,Grabowski, Edward J. J.,Heid, Richard,Kubryk, Michele,Mathre, David J.,Varsolona, Richard

, p. 3581 - 3587 (2003)

(R)-3,5-Bistrifluoromethylphenyl ethanol...

Effective synthesis of (S)-3,5-bistrifluoromethylphenyl ethanol by asymmetric enzymatic reduction

Pollard, David,Truppo, Matthew,Pollard, Jennifer,Chen, Cheng-yi,Moore, Jeffrey

, p. 554 - 559 (2006)

The synthesis of (S)-3,5-bistrifluoromet...

P/S ligands derived from carbohydrates in Rh-catalyzed hydrosilylation of ketones

Khiar, Noureddine,Leal, Manuel Pernia,Navas, Raquel,Moya, Juan Francisco,Perez, Maria Victoria Garcia,Fernandez, Inmaculada

, p. 355 - 360 (2012)

Reported is the synthesis of a number of...

Influence of cofactor regeneration strategies on preparative-scale, asymmetric carbonyl reductions by engineered escherichia coli

Dascier, Dimitri,Kambourakis, Spiros,Hua, Ling,David Rozzell,Stewart, Jon D.

, p. 793 - 800 (2014)

This study was designed to determine whe...

Purification and characterization of a new carbonyl reductase from Leifsonia xyli HS0904 involved in stereoselective reduction of 3,5-bis(trifluoromethyl) acetophenone

Wang, Nengqiang,Huang, Jin,Luo, Hongdou,Wang, Pu,Li, Jun

, p. 1 - 6 (2013)

Leifsonia xyli HS0904 can stereoselectiv...

High-yielding metalloenzymatic dynamic kinetic resolution of fluorinated aryl alcohols

Bogár, Krisztián,B?ckvall, Jan-E.

, p. 5471 - 5474 (2007)

Dynamic kinetic resolution (DKR) of vari...

From imine to amine: An unexpected left turn.: Cis -β Iron(II) PNNP′ precatalysts for the asymmetric transfer hydrogenation of acetophenone

Demmans, Karl Z.,Seo, Chris S. G.,Lough, Alan J.,Morris, Robert H.

, p. 6531 - 6541 (2017)

A novel PNN ligand bearing an orthopheny...

Half-sandwich ruthenium catalyst bearing an enantiopure primary amine tethered to an N-heterocyclic carbene for ketone hydrogenation

Wan, Kai Y.,Sung, Molly M. H.,Lough, Alan J.,Morris, Robert H.

, p. 6827 - 6842 (2017)

By using a copper transmetalation reagen...

Enzymatic preparation of optically pure t-butyl 6-chloro-(3R,5S)-dihydroxyhexanoate by a novel alcohol dehydrogenase discovered from Klebsiella oxytoca

Xu, Tingting,Wang, Can,Zhu, Shaozhou,Zheng, Guojun

, p. 72 - 79 (2017)

Alcohol dehydrogenases can catalyze the ...

Enantioselective ketone hydrogenation: From R&D to pilot scale with industrially viable Ru/phosphine-oxazoline complexes

Naud, Frederic,Spindler, Felix,Rueggeberg, Carsten J.,Schmidt, Andreas T.,Blaser, Hans-Ulrich

, p. 519 - 523 (2007)

The development of a pilot process for t...

Inversion of enantioselectivity in the platinum-catalyzed hydrogenation of substituted acetophenones

Hess, Reto,Vargas, Angelo,Mallat, Tamas,Buergi, Thomas,Baiker, Alfons

, p. 117 - 128 (2004)

The enantioselective hydrogenation of ri...

Mn(i) phosphine-amino-phosphinites: a highly modular class of pincer complexes for enantioselective transfer hydrogenation of aryl-alkyl ketones

Jayaprakash, Harikrishnan

supporting information, p. 14115 - 14119 (2021/10/25)

A series of Mn(i) catalysts with readily...

Copper-catalyzed asymmetric reductions of aryl/heteroaryl ketones under mild aqueous micellar conditions

Etemadi-Davan, Elham,Fialho, David M.,Gadakh, Amol,Langner, Olivia C.,Lipshutz, Bruce H.,Sambasivam, Ganesh,Takale, Balaram S.

supporting information, p. 3282 - 3286 (2021/05/29)

Enantioselective syntheses of nonracemic...

Method for refining chiral alcohol


Paragraph 0102-0143, (2021/04/10)

The invention relates to a method for re...

Cobalt-catalyzed asymmetric hydrogenation of ketones: A remarkable additive effect on enantioselectivity

Du, Tian,Wang, Biwen,Wang, Chao,Xiao, Jianliang,Tang, Weijun

supporting information, p. 1241 - 1244 (2020/10/02)

A chiral cobalt pincer complex, when com...

127852-28-2 Process route

vinyl acetate

vinyl acetate









Conditions Yield
With Novozyme-435 lipase; In tetrahydrofuran; at 20 ℃; for 72h; Resolution of racemate; Enzymatic reaction;
89 % ee
Candida antartica lipase B; In various solvent(s); at 40 ℃; for 2h; under 67505.4 Torr;
Isopropenyl acetate

Isopropenyl acetate









Conditions Yield
With Novozyme-435 lipase; In tetrahydrofuran; at 20 ℃; for 72h; Resolution of racemate; Enzymatic reaction;
86 % ee

127852-28-2 Upstream products

  • 112981-69-8

    3,5-bis(trifluoromethyl)phenylmagnesium bromide

  • 75-07-0


  • 30071-93-3

    3,5-bis(trifluoromethyl)phenyl methyl ketone

  • 849674-12-0


127852-28-2 Downstream products

  • 349-59-7


  • 30071-93-3

    3,5-bis(trifluoromethyl)phenyl methyl ketone

  • 225920-05-8


  • 368-63-8