• Product Name:(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
  • Molecular Formula:C10H8F6O
  • Molecular Weight:258.163

Product Details



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1.What is the (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol ?

(R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanol is a key chiral intermediate in the synthesis of EMEND. Two complementary approaches for the enantioselective reduction of 1-[3,5-bis(trifluoromethyl)phenyl]ethanone are microbial versus asymmetric reduction of ketones through asymmetric hydrogen transfer.

2.What is the CAS number for (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol ?

The CAS number of (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is 127852-28-2.

More information of (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 127852-28-2 are:

CAS Number

European Community (EC) Number 603-245-7
DSSTox Substance ID DTXSID80381243
Nikkaji Number J1.427.078G
Wikidata Q72447321


1.376 g/cm3

Melting Point


Boiling Point

175.8 °C at 760 mmHg

Flash Point

60.1 °C

Vapor Pressure

0.746mmHg at 25°C

Refractive Index








3.What are another words for 127852-28-2 ?

Synonyms for (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 127852-28-2:Benzenemethanol,a-methyl-3,5-bis(trifluoromethyl)-,(R)-;(1R)-1-[3,5-Bis(Trifluoromethyl)phenyl]ethanol;

4.What is the molecular formula of CAS 127852-28-2?

The chemical formula of  (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is C10H8F6O which containing 10 Carbon atoms,8 Hydrogen atoms,6 Fluorine atoms and 1 Oxygen atoms,and the molecular weight of  (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is 258.163.

5.What is (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol (127852-28-2) used for?

(R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanol was synthesized in 98% yield with >99% ee using the immobilized ketoreductase in a 50% hexanes/40% IPA/10% water solvent system. 1-[3,5-Bis(trifluoromethyl)phenyl]ethanone is a key precursor of (R)-1-[3,5-bis-(trifluoromethyl)phenyl]ethanol (R)-2, a sub-structure of the tachykinin NK1 receptor antagonist L-754030, a potent anti-depressant. Its structure is closely related to the structure of MK869, shown recently to be efficient in patients with major depressive disorder.

Isomeric SMILES: C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O  

Relevant articles related to (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol:



A convergent approach to the synthesis of aprepitant: a potent human NK-1 receptor antagonist

Elati, Chandrashekar R.,Kolla, Naveenkumar,Gangula, Srinivas,Naredla, Anitha,Vankawala, Pravinchandra J.,Avinigiri, Muttu L.,Chalamala, Subrahmanyeswararao,Sundaram, Venkatraman,Mathad, Vijayavitthal T.,Bhattacharya, Apurba,Bandichhor, Rakeshwar

, p. 8001 - 8004 (2007)

Carbonyl reductase identification and development of whole-cell biotransformation for highly efficient synthesis of (R)-[3,5-bis(trifluoromethyl)phenyl] ethanol

Kangling Chen, Kefei Li, Jian Deng, Baoqi Zhang, Jinping Lin & Dongzhi Wei

, Microbial Cell Factories volume 15, Article number: 191 (2016)

Total production of (R)-3,5-bistrifluoromethylphenyl ethanol by asymmetric reduction of 3,5-bis(trifluoromethyl)-acetophenone in the submerged culture of Penicillium expansum isolate

Kurbanoglu, Esabi B.,Zilbeyaz, Kani,Taskin, Mesut,Kurbanoglu, Namudar I.

, p. 2759 - 2763 (2009)

6.High Purity 127852-28-2 In Stock In Bulk Supply with Wholesale Price.

Senova Pharma is a quality supplier of (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol. Our main goal is customer satisfaction. Contact us to negotiate the wholesale price for your business on high purity (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 127852-28-2.