SENOVA PHARMA
- +86 185 8909 5435
- sales@senovaph.com
Your Location：Home >Products >Chemical Reagents >127852-28-2
pd_meltingpoint:53-58℃
Purity:99%
Quality products make an important contribution to long-term revenue and profitability.
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is an intermediate in the synthesis of Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.
vinyl acetate
1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol
(R)-O-acetyl-1-(3,5-bis(trifluoromethyl)phenyl)ethanol
(S)-3,5-bis(trifluoromethyl)-1-phenylethanol
(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol
| Conditions | Yield |
|---|---|
|
With Novozyme-435 lipase; In tetrahydrofuran; at 20 ℃; for 72h; Resolution of racemate; Enzymatic reaction;
|
40% 89 % ee |
|
Candida antartica lipase B; In various solvent(s); at 40 ℃; for 2h; under 67505.4 Torr;
|
Isopropenyl acetate
1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol
(R)-O-acetyl-1-(3,5-bis(trifluoromethyl)phenyl)ethanol
(S)-3,5-bis(trifluoromethyl)-1-phenylethanol
(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol
| Conditions | Yield |
|---|---|
|
With Novozyme-435 lipase; In tetrahydrofuran; at 20 ℃; for 72h; Resolution of racemate; Enzymatic reaction;
|
38% 86 % ee |
The CAS number of (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is 127852-28-2.
More information of (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 127852-28-2 are:
|
CAS Number |
127852-28-2 |
|
Density |
1.376 g/cm3 |
|
Melting Point |
53-58℃ |
|
Boiling Point |
175.8 °C at 760 mmHg |
|
Flash Point |
60.1 °C |
|
Vapor Pressure |
0.746mmHg at 25°C |
|
Refractive Index |
1.418 |
|
HS CODE |
29062990 |
|
PSA |
20.23000 |
|
LogP |
3.77750 |
|
Pka |
13.99±0.20(Predicted) |
Synonyms for (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 127852-28-2:Benzenemethanol,a-methyl-3,5-bis(trifluoromethyl)-,(R)-;(1R)-1-[3,5-Bis(Trifluoromethyl)phenyl]ethanol;
The chemical formula of (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is C10H8F6O which containing 10 Carbon atoms,8 Hydrogen atoms,6 Fluorine atoms and 1 Oxygen atoms,and the molecular weight of (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is 258.163.
InChI:InChI=1/C10H8F6O/c1-5(17)6-2-7(9(11,12)13)4-8(3-6)10(14,15)16/h2-5,17H,1H3
Relevant articles related to (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol:
|
Article |
Source |
|
A convergent approach to the synthesis of aprepitant: a potent human NK-1 receptor antagonist |
Elati, Chandrashekar R.,Kolla, Naveenkumar,Gangula, Srinivas,Naredla, Anitha,Vankawala, Pravinchandra J.,Avinigiri, Muttu L.,Chalamala, Subrahmanyeswararao,Sundaram, Venkatraman,Mathad, Vijayavitthal T.,Bhattacharya, Apurba,Bandichhor, Rakeshwar , p. 8001 - 8004 (2007) |
|
Total production of (R)-3,5-bistrifluoromethylphenyl ethanol by asymmetric reduction of 3,5-bis(trifluoromethyl)-acetophenone in the submerged culture of Penicillium expansum isolate |
Kurbanoglu, Esabi B.,Zilbeyaz, Kani,Taskin, Mesut,Kurbanoglu, Namudar I. , p. 2759 - 2763 (2009) |
Senova Pharma is a quality supplier of (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 127852-28-2.