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Purity:99%
The invention relates to a preparation m...
A new protocol for the synthesis of chir...
Rotigotine is a launched drug for the tr...
The present invention provides an altern...
(S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-naphthalen-2-ammonium (R)-2-(2-chlorophenyl)-2-hydroxyacetate

(S)-(-)-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride
| Conditions | Yield |
|---|---|
|
With hydrogenchloride; In tetrahydrofuran; water; at 65 ℃; for 0.25h;
|
94% |
|
With hydrogenchloride; In tetrahydrofuran; water; at 60 - 65 ℃; for 2.25h; Reflux;
|
94% |
(S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-naphthalen-2-ammonium (S)-2-hydroxy-3-phenylpropionate

(S)-(-)-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride
| Conditions | Yield |
|---|---|
|
(S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-naphthalen-2-ammonium (S)-2-hydroxy-3-phenylpropionate; With sodium hydroxide; In 2-methyltetrahydrofuran; water; at 20 ℃;
With hydrogenchloride; In 2-methyltetrahydrofuran; water; at 60 ℃;
|
84% |
|
(S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-naphthalen-2-ammonium (S)-2-hydroxy-3-phenylpropionate; With sodium hydroxide; In 2-methyltetrahydrofuran; water; at 20 ℃;
With hydrogenchloride; In 2-methyltetrahydrofuran; water; at 60 ℃;
|
84% |
(3aS,9bR)-6-methoxy-3-propyl-3,3a,4,5-tetrahydronaphtho[2,1-d]oxazol-2(9bH)-one
SKF 87967 hydrochloride
2-(N-propylamino)-5-methoxytetraline
(S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-naphthalen-2-ammonium (R)-2-(2-chlorophenyl)-2-hydroxyacetate
(S)-1,2,3,4-tetrahydro-5-hydroxy-N-propyl-naphthalen-2-ammonium hydrobromide
(2S)-5-hydroxy-2-(di-n-propylamino)tetralin
rotigotine
rotigotine hydrochloride